目的探讨乙型肝炎病毒抗HBc-IgG与抗HBc-IgM检测的差异及其临床意义。方法 324例血清标本同时测定抗HBc-IgG与抗HBc-IgM,前者是按常用竞争法,后者用捕捉法进行。结果抗HBc-IgM的检测在急性乙型肝炎的诊断中较抗HBc-IgG的检测更有价值。结论抗HBc-IgM的检测在急性乙型肝炎发病机制中起着重要的作用,并可为这些肝病的临床治疗研究提供新的参考意义的数据。 Objective To investigate the difference between anti-HBc-IgG and anti-HBc-IgM in hepatitis B virus (HBV) and its clinical significance. Methods 324 cases of serum samples were tested simultaneously anti-HBc-IgG and anti-HBc-IgM, the former is based on commonly used competition method, the latter by the capture method. Results The detection of anti-HBc-IgM was more valuable than the anti-HBc-IgG in the diagnosis of acute hepatitis B Conclusion The detection of anti-HBc-IgM plays an important role in the pathogenesis of acute hepatitis B, and can provide new reference data for the clinical treatment of these liver diseases.