目的观察兰索拉唑治疗消化道溃疡上消化道出血的综合临床疗效。方法 164例消化道溃疡上消化道出血患者,随机分为对照组和观察组,每组82例。对照组给予法莫替丁联合克拉霉素胶囊,阿莫西林的三联法治疗;观察组给予兰索拉唑联合克拉霉素胶囊,阿莫西林的三联法治疗。两组疗程均为8周。治疗后观察两组患者的临床疗效、临床症状缓解情况、止血时间、幽门螺杆菌(Hp)的根除率及不良反应。结果观察组止血时间为(5.34±0.65)d,Hp根除率为85.4%;对照组止血时间为(7.61±1.06)d,Hp根除率为70.7%;观察组止血时间及Hp的根除率均明显优于对照组(P<0.05)。观察组治疗总有效率为93.90%,明显高于对照组的78.05%,差异具有统计学意义(P<0.05)。两组患者用药期间的不良反应均较轻微,停药后3~4 d症状消失。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论应用兰索拉唑治疗消化道溃疡上消化道出血,止血时间短,不良反应少,疗效显著,值得临床广泛推广。 Objective To observe the comprehensive clinical efficacy of lansoprazole in the treatment of upper digestive tract hemorrhage of peptic ulcer. Methods 164 cases of upper gastrointestinal bleeding in patients with peptic ulcer were randomly divided into control group and observation group, 82 cases in each group. The control group was given famotidine combined with clarithromycin capsules and amoxicillin triple therapy. The observation group was given lansoprazole combined with clarithromycin capsules and amoxicillin triple therapy. The two groups were treated for 8 weeks. After treatment, the clinical efficacy, clinical symptoms, hemostasis time, Helicobacter pylori (Hp) eradication rate and adverse reactions were observed. Results The hemostasis time was (5.34 ± 0.65) days in the observation group and 85.4% in the Hp group. The bleeding time in the control group was (7.61 ± 1.06) days and the Hp eradication rate was 70.7%. The hemostasis time and Hp eradication rate Better than the control group (P <0.05). The total effective rate of observation group was 93.90%, which was significantly higher than 78.05% of control group, the difference was statistically significant (P <0.05). Adverse reactions during the two groups of patients were minor, 3 to 4 d after withdrawal symptoms disappear. There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Lansoprazole treatment of upper gastrointestinal bleeding in patients with peptic ulcer, bleeding time is short, less adverse reactions, the effect is significant, it is widely recommended in clinical.