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目的探讨激素合成障碍性甲肿和桥本甲状腺炎的核医学诊断特征。方法用放射免疫法和免疫放射法测定桥本甲状腺炎和激素合成障碍性甲状腺肿病人血清ＴＴ_３， ＴＴ_４， ＦＴ_３， ＦＴ_４， ＴＳＨ以及ＴＧＡｂ、 ＴＭＡｂ，并进行摄~（１３１）Ⅰ试验以及~（１３１）Ⅰ过氯酸钾释放试验，结果该类病人血清甲状腺激素水平降低，ＴＳＨ水平反馈性升高，摄~（１３１）Ⅰ率增加，~（１３１）Ⅰ过氯酸钾释放试验呈阳性。结论该类病人甲状腺腺泡细胞过氧化物酶缺陷或活性降低，甲状腺激素合成减少，反馈性引起ＴＳＨ分泌增加，高水平ＴＳＨ刺激甲状腺腺泡上皮细胞增生，导致甲状腺肿大，测定血清ＴＧＡｂ和 ＴＭＡｂ对于鉴别诊断上述疾病具有重要意义。
Objective To investigate the characteristics of nuclear medicine diagnosis of hormone-synthesizing obstructive thyroiditis and Hashimoto’s thyroiditis. Methods Serum levels of TT_3, TT_4, FT_3, FT_4, TSH, TGAb and TMAb in patients with Hashimoto’s thyroiditis and hormone-synthesizing obstructive thyroiditis were determined by radioimmunoassay and radioimmunoassay. ) Ⅰ potassium perchlorate release test, the results of such patients to reduce serum thyroid hormone levels, TSH level feedback increased, the rate of ~ (131) Ⅰ increased, ~ (131) Ⅰ potassium hypochlorite release test was positive. Conclusion The thyroid acinar cells in this group had decreased or decreased peroxidase deficiency or thyroid hormone synthesis, increased TSH secretion caused by feedback, high level of TSH stimulated proliferation of thyroid acinar epithelial cells, resulting in goiter and serum TGAb and TMAb For the differential diagnosis of the above diseases is of great significance.