转化生长因子-α(TGF-α)和表皮生长因子(EGF)是刺激上皮增生的多肽物质。这两种多肽行使其生物效应与表皮生长因子受体(EGF受体)相互作用导致DNA合成细胞分裂。EGF受体存在于许多正常细胞及增生部位的上皮中。TGF-α最先在培养的条件下引起正常哺乳动物细胞的可逆性转化而被发现和确认。免疫反应性TGF-α现已被证实存在于肺、胰、结肠、膀胱、卵巢、胃等的恶性肿瘤中和神经胶质瘤中。人的某些外分泌腺、小肠的Paneth氏细胞及肾脏则发现有EGF。EGF在恶性肿瘤中也已被检出,学者们提出EGF可作为胃癌高度恶性变的一种生物标记。采用免 Transforming growth factor-alpha (TGF-alpha) and epidermal growth factor (EGF) are polypeptide substances that stimulate epithelial hyperplasia. Both of these polypeptides exert their biological effects in interacting with epidermal growth factor receptors (EGF receptors) leading to the division of DNA-synthesizing cells. The EGF receptor is present in the epithelium of many normal cells and hyperplastic sites. TGF-α was first discovered and confirmed by causing reversible transformation of normal mammalian cells under culture conditions. Immunoreactive TGF-α has now been shown to be present in gliomas in malignant tumors of lung, pancreas, colon, bladder, ovary, stomach and the like. Certain human exocrine glands, small intestine Paneth cells and kidneys were found to have EGF. EGF has also been detected in malignant tumors, and scholars have suggested that EGF can serve as a biomarker of gastric cancer with a high degree of malignancy. Use free