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钙敏作用是治疗心力衰竭 (CHF )的新途径 ,钙敏剂通过增加收缩蛋白对钙离子的敏感性增加心肌的收缩力 ,而不影响细胞内钙离子的水平。钙敏作用可分为三种 ,增加肌钙蛋白对钙离子的亲和力 ;促进肌钙蛋白和肌浆球蛋白的相互作用 ;改变钙结合信息。
Calcium sensitization is a new way to treat heart failure. Calcium sensitizer increases myocardial contractility by increasing the sensitivity of contractile proteins to calcium ions without affecting intracellular calcium levels. Calcium sensitivity can be divided into three kinds, increase the troponin affinity for calcium; promote the interaction of troponin and sarcolemmal; change the calcium binding information.