过去认为宿主对感染引起严重败血症的应答是侵入细菌毒素的直接作用。现已明确这些有害的反应是由宿主自身产生的介质引起,是这些介质扩大并增强了细菌的信号而损害宿主。作为内源性介质的TNF是一种细胞激动素,当其大量释放时可导致 In the past, the host’s response to infection causing severe sepsis was thought to be a direct effect of invading bacterial toxins. It has now been clear that these deleterious reactions are caused by the host’s own media, which expands and enhances the bacterial signals that damage the host. As an endogenous mediator, TNF is a cytokine that can be produced when it is released in large quantities