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目的 探讨微血管密度 (MVD)和p2 7蛋白在结直肠癌中的表达及其临床意义。方法 应用免疫组化SP法检测结直肠癌中 p2 7的表达 ,以Ⅷ因子相关抗原作为血管内皮细胞标记物测定其MVD。 结果 5 9例结直肠癌中 ,淋巴结转移组MVD高表达、p2 7低表达 ;无淋巴结转移组MVD低表达、p2 7高表达 (P <0 .0 5 )。MVD低表达组、p2 7高表达组 5年生存率明显高于MVD高表达组、p2 7低表达组 (P <0 .0 5 )。MVD低表达、p2 7高表达组 5年生存率明显高于MVD高表达、p2 7低表达组 (P <0 .0 5 )。p2 7高表达组MVD明显低于 p2 7低表达组 (P <0 .0 5 )。 结论 MVD、p2 7的表达与结直肠癌的生物学行为及预后密切相关 ,p2 7、MVD表达呈负相关 ,检测MVD、p2 7在判断结直肠癌患者预后方面有重要意义。
Objective To investigate the expression and clinical significance of microvessel density (MVD) and p27 protein in colorectal cancer. Methods Immunohistochemical SP method was used to detect the expression of p27 in colorectal cancer. VIII factor-associated antigen was used as a marker of vascular endothelial cells to determine its MVD. Results In 59 colorectal cancers, the expression of MVD was high in lymph node metastasis group and low in p27; the low expression of MVD and high expression of p27 in lymph node metastasis group (P < 0.05). The 5-year survival rate in the low-expression MVD group and the high-expression p2-7 group was significantly higher than that in the high-expression MVD group and the low-expression p2-7 group (P < 0.05). The 5-year survival rate of MVD low expression and high p2-7 expression group was significantly higher than that of MVD high expression and p2-7 low expression group (P < 0.05). The MVD in the p2-7 high expression group was significantly lower than that in the p27 low expression group (P < 0.05). Conclusion The expression of MVD and p2 7 is closely related to the biological behavior and prognosis of colorectal cancer, and the expression of p27 and MVD is negatively correlated. Detection of MVD and p27 has important significance in judging the prognosis of patients with colorectal cancer.