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目的评价溶栓前后应用低分子肝素（法安明）对梗死相关血管开通率及维持的影响。方法将符合溶栓标准的８３例患者分成法安明组（４２例）和对照组（４１例），法安明组溶栓前给予法安明静注，并在溶栓后 １２ ｈ皮下注射，５０００ Ｕ，每天 ２次，应用 ２周。对照组溶栓后 １２ ｈ皮下给予肝素钙 ７５００ Ｕ，每天 ２次，应用 ２周。观察两组 ９０ ｍｉｎ造影 ＴＩＭＩ３级血流情况及住院期间心脏事件及出血发生率。结果 ９０ ｍｉｎ造影梗死相关血管 ＴＩＭ１３级血流法安明组 ５０％，对照组 ３６． ５％（Ｐ＞０． ０５），住院期间心脏事件、出血发生率法安明组分别为 １４． ３０， ９． ５％，均明显低于对照组 ３９． ０％和 ２９． ２％（ Ｐ＜ ０． ０５）。结论溶栓前后应用低分子肝素有助于提高和维持梗死相关血管再通率。
Objective To evaluate the effect of low molecular weight heparin (FFA) before and after thrombolytic therapy on the rate and maintenance of infarct-related blood vessel. Methods Thirty-three patients eligible for thrombolytic therapy were divided into two groups, 42 patients in the control group and 41 patients in the control group. , 5000 U, 2 times a day for 2 weeks. Twelve hours after thrombolysis, heparin calcium 7500 U was given subcutaneously twice a day in control group for 2 weeks. The TIMI grade 3 blood flow and the incidence of cardiac events and bleeding during hospitalization at 90 min were observed. Results 90 min angiography infarct - related vascular TIM 50 blood flow Amin 50%, control group 36. 5% (P> 0.05), cardiac events during hospitalization, the incidence of bleeding Atherosclerosis group were 14. 30, 9. 5%, both significantly lower than the control group 39. 0% and 29. 2% (P <0.05). Conclusion The application of low molecular weight heparin before and after thrombolysis helps to improve and maintain infarct-related vascular recanalization rate.