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目的 :探讨2型糖尿病患者血清瘦素(Leptin)水平的变化及意义。方法 :采用放射免疫法测定109例2型糖尿病患者及84例非糖尿病对照者的血清瘦素水平 ,观察其与性别、年龄、体重指数(BMI)、腰臀比率(WHR)、空腹血糖(FPG)、糖化血红蛋白(HbAlc)、空腹血浆胰岛素(FINS)等指标的关系。结果 :2型糖尿病组与对照组之间血清瘦素水平无显著性差异 ,但无论是在2型糖尿病患者还是对照者中 ,女性血清瘦素水平明显高于男性 ,老年人血清瘦素水平较中青年人明显增高 ,肥胖组血清瘦素水平显著高于非肥胖组 ,血清瘦素水平与年龄、BMI、男性WHR呈正相关 ,与FINS呈负相关组。结论 :提示血清瘦素水平存在着性别、年龄及体型等方面的差异 ,其变化是否与性激素的调控和瘦素基因表达的下游环节障碍有关有待研究。
Objective: To investigate the changes and significance of serum leptin in type 2 diabetic patients. Methods: Serum leptin levels were measured by radioimmunoassay in 109 patients with type 2 diabetes mellitus and 84 non-diabetic controls. The levels of serum leptin were compared with those of gender, age, body mass index (BMI), waist-hip ratio (WHR), fasting plasma glucose ), Glycosylated hemoglobin (HbAlc), fasting plasma insulin (FINS) and other indicators. Results There was no significant difference in serum leptin level between type 2 diabetes mellitus and control group. However, the level of serum leptin in women with type 2 diabetes was significantly higher than that in males Serum leptin level was significantly higher in obesity group than in non-obese group. Serum leptin level was positively correlated with age, BMI, male WHR and negatively correlated with FINS. Conclusions: It is suggested that the serum leptin level has differences in gender, age and body size. Whether the change is related to the regulation of sex hormones and the downstream links of leptin gene expression needs to be studied.