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增殖细胞核抗原（ProliferatingCellun－clear－antigen，PCNA）又称周期素，由Miyachi等在1978年发现提纯［1］。主要分布在增殖细胞、促有丝分裂剂刺激转化的淋巴细胞，以及实体肿瘤中有增殖能力的细胞。PCNA是DNA多聚酶a的辅助蛋白，是DNA合成必不可少的因子，同时也是一种
Proliferating Cellul-clear-antigen (PCNA), also known as cyclin, was purified in 1978 by Miyachi et al. [1]. Mainly distributed in proliferating cells, mitogenic agents to stimulate the conversion of lymphocytes, and solid tumor cells have proliferative capacity. PCNA is an accessory protein of DNA polymerase a and is an indispensable factor for DNA synthesis as well as a