目前,控制有抗因子Ⅷ抑制物的血友病人的出血发作仍然是一个难题。在输入因子Ⅷ浓缩物后,发生强烈回忆反应的病人尤其如此。已经知道抗因子Ⅷ促凝成份(FⅧ:C)抗体可能是有种属特异性的,这种抗体中和猪因子Ⅷ较中和人因子Ⅷ为少。过去,曾用牛或猪因子Ⅷ浓缩物控制有高滴度抑制物的血友病人的严重出血发作。但是,由于引起某些严重变态反应和过敏反应伴有血小板减少而限制了它们的应用。晚近,一种用聚电解质分级分离法制备的高纯度猪因子 Hemorrhagic seizures of hemophiliacs who control anti-factor Ⅷ inhibitors are still a problem today. This is especially true for those patients who have a strong recall response after entering Factor VIII concentrate. It has been known that anti-Factor VIII procoagulant (FVIII: C) antibodies may be species-specific and that this antibody neutralizes porcine Factor VIII less than neutralized human Factor VIII. In the past, bovine or porcine factor VIII concentrates have been used to control severe bleeding in hemophiliacs with high titers of inhibitors. However, their application has been limited by the serious allergic reactions and the thrombocytopenia associated with allergic reactions. Recently, a high purity porcine factor prepared by polyelectrolyte fractionation