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目的观察川芎素联合坎地沙坦酯治疗高血压的疗效。方法选取高血压患者80例并分为A、B两组,分别采用川芎素或安慰剂加坎地沙坦酯治疗,治疗前后均检测相关临床及生化指标。结果 (1)两组治疗后血压均下降,但A组下降幅度较B组明显。(2)两组治疗后血清ET-1水平较治疗前明显降低,但A组降低较B组显著。(3)经治疗后A组调脂效果显著,而B组调脂效果不明显。结论 A组治疗方案更有利于降压、调脂和改善血管内皮功能。
Objective To observe the therapeutic effect of sodium ferulate combined with candesartan cilexetil on hypertension. Methods Eighty hypertensive patients were selected and divided into groups A and B, respectively. The patients were treated with canrimazarin sodium or placebo plus candesartan cilexetil. The clinical and biochemical indexes were measured before and after treatment. Results (1) After treatment, blood pressure decreased in both groups, but the decrease in group A was more obvious than that in group B. (2) After treatment, the level of serum ET-1 in the two groups was significantly lower than that before treatment, but the decrease in group A was more significant than that in group B. (3) After treatment, lipid-lowering effect of group A was significant, but lipid-lowering effect of group B was not obvious. Conclusion A group of treatment programs are more conducive to antihypertensive, lipid-lowering and improve vascular endothelial function.