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目的评价缓释5-氟脲嘧啶腹腔植入治疗恶性腹水的疗效及毒性。方法晚期肿瘤合并恶性腹水40例,采用中人氟安植入腹腔内进行灌注化疗,每14d治疗1次,每4次为1疗程。结果全组40例中,治疗完全缓解18例,部分缓解12例,稳定6例,进展4例,总有效率75%。主要毒副反应为腹泻。患者耐受性良好。结论中人氟安腹腔植入治疗对于晚期肿瘤合并恶性腹水患者具有疗效高、毒副反应少的特点,值得临床上进一步推广使用。
Objective To evaluate the efficacy and toxicity of sustained-release 5-fluorouracil intraperitoneally for the treatment of malignant ascites. Methods Forty patients with malignant ascites were enrolled in this study. Fluorouracil was implanted intraperitoneally for perfusion chemotherapy, once every 14 days and once every 4 times. Results Among the 40 cases, the complete remission was treated in 18 cases, partial remission in 12 cases, stable in 6 cases and progression in 4 cases, the total effective rate was 75%. The main side effects of diarrhea. Patients are well tolerated. Conclusion Intraperitoneal fluorine Ann intraperitoneal implantation for patients with advanced malignant ascites due to high efficacy, fewer side effects, it is worth further promotion of the clinical use.