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The histamine receptor antagonists in the treatment of allergic disease have limitations.The treatments of Chinese herbs have some curative effects on allergic skin lesions.Present research indicates that the mitogen-activated protein kinase (MAPK) signaling pathway might be equally important in allergic reactions.It was found that the inhibition of MAPK signaling pathways might relieve allergy symptoms,and some herbs can inhibit the MAPK pathway,which yields anti-allergy effects.Chinese medicines (CMs) have immense potential in the development of treatments for allergic disease.