中国科学技术大学单革研究组发明了一种新的筛选方法,可筛选出能特异针对具有细微改变(比如单氨基酸残基突变)蛋白质的核酸(RNA)适配体。RNA适配体是人工合成及筛选出的能特异结合小分子、蛋白质,甚至完整细胞的非编码RNA。RNA适配体的筛选利用了足够复杂的RNA序列库所具有的类似抗体一样的结合多样性和特异性潜能。RNA适 The Institute of Single Leather Science, University of Science and Technology of China, invented a new screening method to screen for nucleic acid (RNA) aptamers that are specific for proteins with subtle changes such as single amino acid residue mutations. RNA aptamers are synthetic and screened non-coding RNAs that bind specifically to small molecules, proteins, and even whole cells. Screening for RNA aptamers exploits the similar binding diversity and specificity potential of similar antibodies found in RNA libraries of sufficient complexity. RNA suitable