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大剂量β受体阻滞剂主要引起心动过缓、低血压,低排出量心力衰竭和心原性休克。甲磺胺心定(Sotalol)为非选择性β受体阻滞剂,无内源性拟交感和稳定膜活性.本品与其他β受体阻滞剂不同,高浓度时能延长犬心室肌和浦顷野纤维动作电位时限一本文系第一次报告二例甲磺胺心定严重中毒,特点是与药物浓度有关的Q-T间期延长,严重快速心律失常的敏感性显著增加。患者为39岁和59岁男性,分别在吞服甲磺胺心定2.4克后2小时和服用8克后3小时入院.最低心率分别为50和45次/分.收缩压80～85毫米汞柱,舒张压50～55毫米汞柱.血压分别经滴注多巴胺或异丙基肾上腺素回升。例一于中毒
High-dose beta-blockers mainly cause bradycardia, hypotension, low-output heart failure and cardiogenic shock. Sotalol is a non-selective beta-blocker with no endogenous sympathomimetic and stable membrane activity Unlike other beta-blockers, Sotalol prolongs the canine ventricular muscle and Pu are wild fiber action potential time limit of a This article is the first report of two cases of methanesulfonamide serious poisoning, characterized by drug-related QT prolongation, the sensitivity of severe tachyarrhythmia increased significantly. The patients, aged 39 and 59, were admitted to the hospital at 2 hours after ingesting 2.4 g of mesylate and 3 hours after taking 8 grams, with a minimum heart rate of 50 and 45 beats / min and a systolic blood pressure of 80 to 85 mmHg , Diastolic blood pressure 50 ~ 55 mm Hg.The blood pressure was dropped by dopamine or isoprenaline up. One example is poisoning