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目的了解阜宁县儿童预防接种工作质量和免疫规划相关疾病人群免疫水平,完善不同人群的乙肝免疫策略。方法对抽取的5个镇0~岁以上8个年龄组计400名健康人群,采用酶联免疫吸附试验法检测抗-HBs。结果 400名健康人群接种三针5ug重组酵母乙肝疫苗后,抗-HBs阳性率84.5%,各年龄组、各镇抗-HBs阳性率的差异均有统计学意义。结论在15岁以下人群中抗-HBs阳性率有随着年龄的增加其免疫成功率逐渐下降的趋势,需要加强接种,且须提高乙肝疫苗接种剂量,建议纳入国家免疫程序;要做好中小学生乙肝疫苗查漏补种工作,重点人群、高危人群及成人的乙肝疫苗接种工作;要加强医疗机构乙肝疫苗/乙肝免疫球蛋白产房接种,加大疫苗接种剂量,强化接种合格率与及时接种率,提高免疫成功率,降低HBs Ag携带率和乙肝发病率。疾控机构应定期对辖区内相应人群开展免疫成功率监测。
Objective To understand the quality of vaccination work in Funing County and the immunization level of immunization-related diseases, and to improve the hepatitis B immunization strategies in different populations. Methods Four healthy volunteers were enrolled in the study. The anti-HBs were detected by enzyme-linked immunosorbent assay. Results The results showed that the positive rate of anti-HBs was 84.5% in 400 healthy people vaccinated with three doses of 5ug recombinant yeast hepatitis B vaccine. The positive rates of anti-HBs in all age groups and towns were all statistically significant. Conclusions The positive rate of anti-HBs in the population under 15 years of age tends to decrease gradually with the increase of the age, so vaccination should be strengthened and the dose of hepatitis B vaccine should be raised. It is recommended to include the national immunization program. Hepatitis B vaccine leak detection and replantation work, key populations, high-risk groups and adults of hepatitis B vaccination work; to strengthen the medical institutions of hepatitis B vaccine / hepatitis B immunoglobulin delivery room vaccination, increase the vaccination dose, and strengthen the vaccination pass rate and timely vaccination rate, Improve the success rate of immunization, reduce the HBs Ag carrier rate and hepatitis B incidence. CDC should regularly conduct surveillance on the success rate of immunization against the corresponding population in its jurisdiction.