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实验用离体猪脑血管标本（基底动脉环）研究组胺（His）及其受体拮抗剂对脑血管舒缩作用的影响。His10(-5)mol／L使脑血管收缩，达最大张力（055±0.14）g，但维持时间较短，随之血管舒张。H1受体拮抗剂苯海拉明、扑尔敏可拮抗His对脑血管的收缩作用，并使His的量一改曲线平行右移，最大反应不压低，其PA2值分别为8.54和9.67。H2受体拮抗剂西米替了、雷尼替了可拮抗His的舒血管效应，使其量一效曲线左移。结果表明，在猪脑血管上存在着不同的His受体亚型，分别参与对猪脑血管舒编作用的调节。
Effects of histamine (His) and its receptor antagonist on the vasoconstriction of cerebrovascular vasoconstriction in experimental porcine cerebrovascular samples (basilar artery rings). His10 (-5) mol / L caused cerebral vasoconstriction up to the maximum tension (055 ± 0.14) g, but the maintenance time was shorter, followed by vasodilation. H1 receptor antagonist diphenhydramine and chlorpheniramine can antagonize the contraction of cerebral blood vessels by His and change the amount of His to the right parallel and the maximal response does not decrease. The PA2 values are 8.54 and 9.67, respectively. Simvastatin H2 antagonist, ranitidine can antagonize His vasodilator effect, so that the effect of a dose-effect curve to the left. The results showed that there are different His receptor subtypes in pig blood vessels, which are respectively involved in the regulation of blood vessel soothing in pigs.