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我们试用微晶法制备利凡诺微晶,提高了在注射用水中的溶解速率。一、实验用药品及仪器利凡诺:辽源市制药二厂,批号791212无水乙醇:沈阳市试剂一厂,化学纯,批号841107乙醚:西安化学试剂厂,化学纯,批号83112990型无级调速电动搅拌机,转速6000r/min二、利凡诺结晶的制备传统法:取500ml近沸(78℃)无水乙醇逐渐溶入24g利凡诺,乘热保温过滤,滤液置容器内密塞,放置冰箱中冷藏二昼夜,过滤,沉淀于80℃以下干燥,研碎备
We experimented with the microcrystalline method for the production of rivano crystallites, increasing the rate of dissolution in water for injection. First, the experimental drugs and equipment rivanol: Liaoyuan Pharmaceutical Factory No. 791212 anhydrous ethanol: Shenyang Reagent Factory, chemical pure, lot number 841107 Ethyl ether: Xi’an Chemical Reagent Factory, chemical pure, batch No. 83112990 no grade Speed electric mixer, speed 6000r / min Second, the production of rivanol crystal traditional method: Take 500ml nearly boiling (78 ℃) ethanol gradually dissolved into 24g rivanol, by heat insulation filter, the filtrate was placed inside the container sealed, placed Refrigeration refrigerator two days and nights, filtration, precipitation below 80 ℃ drying, grinding preparation