目的：比较５～７ 天龄，５ ～６ 月龄以及１８ 月龄大鼠胸主动脉血管功能性α１肾上腺素受体（α１ａｄｒｅｎｏｃｅｐｔｏｒ，α１ＡＲ） 及其亚型分布。方法：采用离体血管收缩功能实验，利用不同的α１ＡＲ 亚型选择性拮抗剂，分别测定５ ～７天龄，５ ～６ 月龄以及１８ 月龄大鼠胸主动脉血管功能性α１ＡＲ 及其亚型。结果：由去甲肾上腺素（ＮＥ）引起的主动脉最大收缩反应在５～７ 天龄乳鼠显著低于５～６ 月龄及１８ 月龄大鼠。ＷＢ４１０１（α１ＡＡＲ和α１ＤＡＲ选择性拮抗剂）对ＮＥ介导的血管收缩效应的ｐＡ２ 值在５ ～７ 天龄，５～６ 月龄及１８ 月龄大鼠间差异无显著性，ＢＭＹ７３７８（α１ＤＡＲ选择性拮抗剂） 和Ｓｅｒｔｉｎｄｏｌ（α１ＡＡＲ 选择性拮抗剂） 在５～７ 天龄与５ ～６ 月龄大鼠的ｐＡ２ 值间差异也无显著性，但在１８ 月龄大鼠主动脉ＢＭＹ７３７８ 的ｐＡ２ 值显著减小；而Ｓｅｒｔｉｎｄｏｌｅ 的ｐＡ２ 值则明显增大。氯乙基可乐定（ＣＥＣ， 为α１ＢＡＲ和α１ＤＡＲ不可逆阻断剂） 对ＮＥ 引起的胸主动脉收缩的抑制作用在１８ 月龄大鼠明显小于５ ～６ 月龄大鼠。结论：在大鼠的生长过程中，从幼年到成年胸主动脉上的功能性α１ OBJECTIVE: To compare the distribution of α1-adrenoceptor (α1AR) and its subtypes in the thoracic aorta of 5-7-day-old, 5-6-month-old and 18-month-old rats. Methods: In vitro vasoconstriction experiment, the use of different α1  AR subtype selective antagonists were measured 5 to 7 days, 5 to 6 months and 18-month-old rat thoracic aortic vascular function α1  AR and its subtypes. Results: The maximal aortic contraction induced by norepinephrine (NE) was significantly lower in 5-7 day-old neonatal rats than in 5-6-month-old and 18-month-old rats. The pA2 value of WB4101 (α1AAR and α1DAR selective antagonists) on NE-mediated vasoconstriction was not significantly different between 5-7 days, 5-6 months and 18-month-old rats, and BMY7378 (Α1D  AR selective antagonist) and Sertindol (α1A  AR selective antagonist) in 5 to 7 days and 5 to 6 months old rats pA2 value was no significant difference, but at 18 months of age The pA2 value of mouse aorta BMY7378 was significantly reduced, while the pA2 value of Sertindole was significantly increased. Inhibition of NE-induced contraction of thoracic aorta by chloroethyl clonidine (CEC, α1B-AR and α1D-AR irreversible blockers) was significantly less than that of rats aged 5 to 6 months at 18 months of age. CONCLUSIONS: During the growth of rats, the functional α1gene from the young to the adult thoracic aorta