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目的评价地塞米松对食管恶性肿瘤疲乏及其相关症状的临床疗效。方法纳入食管恶性肿瘤患者50例,随机分为治疗组和对照组,分别静脉给予地塞米松及安慰剂,治疗14 d。纳入患者在入组24 h以及疗程结束后完成MDASI量表填写,以治疗前后患者MDASI评分评估疗效。结果治疗后所有纳入患者疲乏症状均有所减轻,且与对照组比较,治疗组患者疲乏评分降低更为显著,组间比较差异具有统计学意义(P<0.05)。此外,两组患者治疗后疼痛、食欲减退、气促、恶心和呕吐等症状也有所减轻,减轻幅度组间差异也具有统计学意义(P<0.05)。结论地塞米松能够在短时间内有效改善肿瘤相关性疲乏,有助于提高晚期肿瘤患者的生活质量。
Objective To evaluate the clinical effect of dexamethasone on the fatigue of esophageal cancer and its related symptoms. Methods Fifty patients with esophageal malignant tumors were randomly divided into treatment group and control group, and received intravenous dexamethasone and placebo respectively for 14 days. The patients were enrolled in the 24 h and after the completion of the course to complete the MDASI scale to assess the efficacy of MDASI score before and after treatment. Results After treatment, all the patients were relieved of fatigue symptoms. Compared with the control group, the fatigue score of the treatment group was more significant, and the difference between the two groups was statistically significant (P <0.05). In addition, the two groups of patients after treatment of pain, loss of appetite, shortness of breath, nausea and vomiting and other symptoms have also been reduced, reduce the magnitude of the difference between groups was also statistically significant (P <0.05). Conclusion Dexamethasone can effectively improve the tumor-related fatigue in a short period of time and help to improve the quality of life of patients with advanced cancer.