大肠癌是一种常见的消化道恶性肿瘤。在西方发达国家,其发病率居恶性肿瘤的第二位,在世界范围内居第三位,在我国其发病率呈上升趋势。大肠肿瘤的发生发展是多基因参与、多步骤、多阶段的复杂过程,在这个过程中,抑癌基因具有重要的作用。神经生长因子1(Netrin-1)受体UNC5C和DCC是近年来在大肠癌中发现的可能的抑癌基因,靶向作用Netrin信号通路不仅对晚期大肠癌有治疗可能,而且对早期癌甚至晚期腺瘤都有治疗可能。 Colorectal cancer is a common gastrointestinal cancer. In western developed countries, the incidence ranks second in malignant tumors, ranks third in the world, and its incidence in our country is on the rise. The occurrence and development of colorectal cancer is a multi-gene involved, multi-step, multi-stage complex process, in the process, tumor suppressor gene has an important role. Netrin-1 receptors, UNC5C and DCC, are possible tumor suppressor genes found in colorectal cancer in recent years. Targeting Netrin signaling pathway is not only possible for the treatment of advanced colorectal cancer, but also for early stage cancer and even advanced stage Adenomas are treated.