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目的:探讨慢性氟中毒对神经元某些酶类的影响,为氟中毒脊髓病临床症状产生的机理提供形态学依据.方法:采用生后40日龄WISTAR系雄性大鼠,以喂饲高氟100PPM/L水的方法制造慢性氟中毒模型.对其脊髓前角运动神经元的镁激活腺苷三磷酸酶(ADENOSINETRIPHOSPHATASE,ATPASE),硫胺素焦磷酸酶(THIAMINEPY－ROPHOSPHATASE,TPPASE),乙酰胆碱酯酶(ACETYLCHOLINESTERASE,ACHE)及胆碱乙酰化酶(CHOLINEACETYLTRANSFERASE,CHAC)进行定性定量研究.结果:氟中毒组脊髓前角神经元的ATPASE,TPPASE及ACHE的活性明显降低,而CHAC的变化不明显.结论:慢性氟中毒对脊髓前角运动神经元的ATPASE,TPPASE及ACHE的活性有明显的影响,而对CHAC的影响不明显.“,”Objective: This study was to explore the effect of chronic fluorosis on fluorosis neuron enzymes and to provide some morphological evidence for the mechanism of the clinical manifestations in fluorosis myelopathy. Methods: Male wistars rats 40 days after birth were fed with high concentration fluorine water (100 ppm/L) for inducing fluorosis. We analysed the Mg 2+ ATPase, TPPase, AChE, and ChAc quanlitatively and quantitatively in the motor neurons at anterior horn of spinal cord. Results: The activit...