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关于硷式水楊酸鉍注射剂的含量测定方法,中国药典是采用称定磷酸鉍沉淀重量后再改算成含鉍量的方法。其他国家药典(如美国药典、日本药局方)亦系采用此法測定鉍的含量。笔者认为,在具体操作中,有二点值得改进,对提高工作效率、简化操作手續、保証檢驗质量均有帮助,现介紹如下。改进操作之一是:用吸管吸取样品的方法改为称定重量取檢品的方法。药典規定:“精密用吸管測出适量,置分液器中,吸管用醚約25 ml洗淨,……”。由于本品是一种白色油混悬液,本身具有很大的粘度。若本品濃度为1ml含0.1g,則須吸取4ml檢品左右,因之,所采用吸管一般为5ml胖肚吸管或刻度吸管。
With respect to the determination method of cesium-type salicylic acid hydrazine injection, the Chinese Pharmacopoeia uses the method of quantitating the weight of cerium phosphate precipitated and then calculating the amount of cerium. Pharmacopoeia of other countries (such as the United States Pharmacopoeia and the Japanese Pharmacopoeia) also use this method to determine the content of thorium. The author believes that in the specific operations, there are two points worth improving, which are helpful for improving work efficiency, simplifying operation procedures, and ensuring the quality of inspections. One of the improvement operations is to change the method of sucking a sample with a suction tube to a method of weighing a sample. The Pharmacopoeia stipulates: “The precise amount is measured by a pipette, and in the dispenser, the pipette is washed with about 25 ml of ether, ...”. Because this product is a white oil suspension, it has a very large viscosity. If the concentration of this product is 1ml containing 0.1g, you must draw about 4ml of the test article, so the straw used is generally 5ml fat belly straw or scale straw.