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目的报道伴有Rathke囊肿的垂体腺瘤,分析其临床病理特征。方法对2例伴Rathke囊肿的垂体腺瘤进行组织病理学和免疫组化研究,结合文献对其临床表现、组织病理学特征和组织学来源进行讨论。结果2例伴Rathke囊肿垂体腺瘤中肿瘤细胞呈多边形,胞质丰富透亮,核圆,大小一致,排列呈巢状及片状,间质内见血窦。瘤组织中央见一囊,内衬单层纤毛柱状上皮。免疫组化:例1瘤细胞FSH(+),囊壁上皮细胞CK、EMA和AB-PAS(+)。结论伴有Rathke囊肿的垂体腺瘤非常罕见,明确诊断依赖于组织病理学观察及免疫组化标记。
Objective To report the pituitary adenoma with Rathke’s cyst and analyze the clinicopathological features. Methods Two cases of pituitary adenomas with Rathke cyst were studied by histopathology and immunohistochemistry, and their clinical manifestations, histopathological features and histological sources were discussed. Results The tumor cells in 2 patients with Rathke cyst pituitary adenoma were polygonal, with rich and translucent cytoplasm, nuclear round, consistent in size, arranged in nests and flakes, and found sinusoids in the interstitium. See a tumor in the central capsule, lined with single-ciliated columnar epithelium. Immunohistochemistry: Example 1 tumor cells FSH (+), cyst epithelial cells CK, EMA and AB-PAS (+). Conclusions Pituitary adenomas with Rathke’s cyst are rare, and their definite diagnosis depends on histopathological observation and immunohistochemical staining.