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目的探讨异丙酚复合瑞芬太尼麻醉对脑膜瘤手术患者血流动力学及SI00B的影响。方法从本院2013年12月至2014年12月收治的脑膜瘤患者中随机选择63例进行研究,随机分为对照组(31例)和观察组(32例),均实施手术治疗,并分别给予异丙酚麻醉和异丙酚复合瑞芬太尼麻醉。于麻醉后1 h(T1)、2 h(T2)、缝合硬膜时(T3)和手术结束时(T4)对两组患者进行采血,检测其血流动力学变化情况,包括血氧饱和度(Sp O2)、心率(HR)、平均动脉压(MAP),并对患者的血清SI00B蛋白含量进行检测。结果观察组患者的血流动力学各项指标在不同时间点均未发生明显的改变(P>0.05);但与对照组各时间点比较,差异均有统计学意义(P<0.05),表明观察组维持了较为稳定的血流动力学状态。麻醉后,两组患者的SI00B蛋白水平均明显上升(P<0.05);两组间比较,差异均有统计学意义(P<0.05)。结论对脑膜瘤手术患者实施异丙酚复合瑞芬太尼麻醉可以维持稳定的血流动力学状态,并可对患者进行脑保护。
Objective To investigate the effects of propofol combined with remifentanil on hemodynamics and SI00B in patients with meningiomas. Methods A total of 63 patients with meningioma admitted from December 2013 to December 2014 in our hospital were randomly divided into control group (n = 31) and observation group (n = 32) Give propofol anesthesia and propofol combined with remifentanil. Blood samples were collected at 1 h (T1), 2 h (T2), at the time of suturing the dura (T3) and at the end of the operation (T4), and their hemodynamic changes were measured, including oxygen saturation (Sp O2), heart rate (HR) and mean arterial pressure (MAP). Serum levels of SI00B protein in patients were also measured. Results The indexes of hemodynamics in the observation group did not change significantly at different time points (P> 0.05), but there were significant differences (P <0.05) with the control group at each time point The observation group maintained a relatively stable hemodynamic status. After anesthesia, SI00B protein levels in both groups were significantly increased (P <0.05). There was significant difference between the two groups (P <0.05). Conclusion Propofol combined remifentanil anesthesia in patients with meningioma surgery can maintain stable hemodynamic status, and brain protection in patients.