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Objective: To investigate cathepsin B(CB) expressionin colorectal carcinoma and its relationship withmicrovessel density (MVD) and biological behavior.Methods: CB and MVD were detected byimmunohistochemistry in 47 cases of colorectal carcinoma. Results: The expression of CB in mucinous colorectalcarcinoma was significantly higher than that inno-mucinous colorectal carcinoma. There was significantdifference (P<0.05). The MVD in group with positive CBwas stronger than that in group with negative CB. There was also significant difference (P<0.05). Conclusion: Theresults suggest that CB expression has correlation withMVD, invasion and metastasis in colorectal carcinoma,especially in mucinous colorectal carcinoma.
Objective: To investigate cathepsin B (CB) expressionin colorectal carcinoma and its relationship with microvessel density (MVD) and biological behavior. Methods: CB and MVD were detected by immunohistochemistry in 47 cases of colorectal carcinoma. Results: The expression of CB in mucinous colorectal carcinoma There was a significant difference (P <0.05). Conclusion: Theresults suggest that that was significantly higher than that of inno-mucinous colorectal carcinoma CB expression has correlation with MVD, invasion and metastasis in colorectal carcinoma, especially in mucinous colorectal carcinoma.