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目的 了解幽门螺杆菌 (Hp)感染在霜斑样病变的形成与转归的作用。方法 检测了接受胃镜检查 192例病人胃窦和球粘膜Hp及球粘膜炎症 ,分析球部Hp与这些指标的关系。把志愿复查的霜斑样病变患者随机分为雷尼替丁与抗Hp治疗组后重复胃镜观察。结果 球部Hp的检出率 ,在不同病变间存在显著差异 (P<0 0 5) ,与胃窦Hp密度相关 (rs=0 556 6 ,P <0 0 5) ;球粘膜炎症程度也存在显著差异 (P <0 0 5) ,与球部Hp定植密度相关 (rs=0 56 15,P <0 0 5)。 2 6例Hp感染的霜斑样病变复查胃镜 ,抗Hp治疗效果显著 (P <0 0 5)。结论 霜斑样病变可能与十二指肠球部Hp定值有关 ,受胃窦HP密度的影响。
Objective To understand the role of Helicobacter pylori (Hp) infection in the formation and prognosis of frostbite-like lesions. Methods The gastritis and globular mucosal inflammation of the gastric antrum and globular mucosa were examined in 192 patients undergoing gastroscopy. The relationship between Hp in the bulb and these indicators was analyzed. Patients who were volunteerly reviewed for frostbite lesions were randomized to repeat gastroscopy after ranitidine and anti-Hp treatment. Results The detection rate of Hp in the bulb was significantly different between different lesions (P <0.05), and was related to the Hp density of gastric antrum (rs = 0 556 6, P <0 05). The degree of ball mucosal inflammation also existed Significant difference (P <0 05) was related to the density of Hp colonization (rs = 0 56 15, P 0 05). Twenty-six cases of Hp-infected frost-like lesions were examined by endoscopy, and anti-Hp treatment was significantly effective (P <0.05). Conclusion frostbite-like lesions may be related to the value of Hp in the duodenal bulb, affected by the density of the antrum of the HP.