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目的探讨来曲唑/尿卵泡刺激素微刺激方案对卵巢低反应患者的治疗结局。方法研究对象为2007年7月至2009年4月在我院生殖中心接受体外受精/卵胞浆内单精子注射(IVF/ICSI)助孕的卵巢低反应患者111例,随机分为两组,60例使用微刺激方案(实验组),51例使用微量长方案(对照组)。对两组的周期取消率、获卵数、可移植胚胎数、临床妊娠率、胚胎种植率等进行比较。结果对照组与实验组的平均获卵数分别为(4.0±1.3)和(3.0±2.0)个,差异有显著性(P<0.05);两组周期取消率、可移植胚胎数、临床妊娠率、胚胎种植率差异无显著性(P>0.05)。结论来曲唑/尿卵泡刺激素微刺激方案对卵巢低反应的患者是一种有效的治疗方案,并且费用低廉。
Objective To investigate the therapeutic effect of letrozole / urinary follicle stimulating hormone micro-stimulation regimen on patients with low ovarian response. Methods A total of 111 ovarian hyporesponsive patients undergoing in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI) assisted fertilization in our hospital from July 2007 to April 2009 were randomly divided into two groups, Sixty patients received micro-stimulation (experimental group) and 51 patients received micro-long protocol (control group). Cycle revocation rate, number of oocytes retrieved, number of transferable embryos, clinical pregnancy rate and embryo implantation rate were compared between the two groups. Results The average number of oocytes retrieved from the control group and the experimental group was (4.0 ± 1.3) and (3.0 ± 2.0), respectively, with significant difference (P <0.05). The cancellation rate, the number of transferable embryos, the clinical pregnancy rate , Embryo implantation rate difference was not significant (P> 0.05). Conclusion Letrozole / urinary follicle stimulating hormone micro-stimulation regimen is an effective treatment for patients with low ovarian response, and the cost is low.