目的探讨胎盘线粒体功能障碍在子痫前期中的作用。方法选取正常妊娠、轻度子痫前期以及重度子痫前期孕妇各15例,对胎盘线粒体形态、膜电位、三磷酸腺苷(ATP)的含量及胎盘内活性氧(ROS)的含量等指标进行观察和检测。结果与正常组比较,轻度子痫、重度子痫组胎盘线粒体超微结构均有改变,膜电位和ATP含量显著降低,ROS升高。结论子痫前期胎盘组织线粒体功能异常可能参与子痫前期发病的重要环节。 Objective To investigate the role of placental mitochondrial dysfunction in preeclampsia. Methods 15 pregnant women with normal pregnancy, mild preeclampsia and severe preeclampsia were selected and their placental mitochondrial morphology, membrane potential, ATP content and content of reactive oxygen species (ROS) in the placenta were observed and measured . Results Compared with the normal group, the ultrastructure of placental mitochondria in mild eclampsia and severe eclampsia were changed, the membrane potential and ATP content were significantly decreased, ROS increased. Conclusion The abnormal placenta mitochondria in preeclampsia may play an important role in the pathogenesis of preeclampsia.