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目的探讨深圳市宝安区2007年0～7岁麻疹发病的原因,找出针对性的措施,控制麻疹发病率。结论选取0～7岁龄儿童,分为0～8月龄,8月龄～7岁两组;采用病例对照研究方法,研究病例组和对照组在医院暴露史、麻疹患者接触史、母亲患麻疹史、母亲疫苗接种史和人口信息等可能的影响因素上的差异,从而确定引起宝安区0～7岁麻疹高发的原因。结果 0～8月龄儿童麻疹医院暴露和麻疹病例接触OR值的95%CI分别为1.6～13、1.03～12.4,母亲患麻疹史和母亲疫苗接种史是保护因素,OR值的95%CI为0.02～0.43、0.05～0.77。方差分析显示,单独麻疹患者接触史尚不能认为是危险因素,而医院暴露史则为危险因素;院内麻疹患者接触史则为强危险因素。结论医院暴露和麻疹病例接触有交互效应;医院暴露和未接种麻疹疫苗有交互效应;医院暴露次数越多,OR值越大;疫苗接种次数越多,OR值越小。
Objective To explore the causes of measles in 0 ~ 7 years old in Baoan District of Shenzhen City in 2007 and find the appropriate measures to control the incidence of measles. Conclusion The children aged 0-7 years were divided into two groups: 0-8 months old and 8 months old ~ 7 years old. The case-control study was used to study the history of hospital exposure, the history of measles contact, Measles history, mother vaccination history and population information and other possible influencing factors in order to determine the cause of high incidence of measles in 0 ~ 7 years old in Baoan District. Results The 95% CIs of OR between the hospitalized and measles patients aged 0 ~ 8 months were 1.6 ~ 13 and 1.03 ~ 12.4, respectively. The history of maternal measles and mother vaccination was the protective factor. The 95% CI of OR was 0.02 ~ 0.43, 0.05 ~ 0.77. Analysis of variance showed that exposure to measles alone could not be regarded as a risk factor but exposure to hospital was a risk factor. Exposure to measles in hospital was a strong risk factor. Conclusion There is an interaction effect between hospital exposure and measles case exposure. Interaction between hospitalized and unvaccinated vaccine is observed. The higher the number of hospital exposure is, the greater the OR value. The higher the frequency of vaccination is, the smaller the OR is.