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目的探讨中性粒细胞单核细胞乘积(NMP)联合血肌酐判断急性胰腺炎严重程度的能力。方法回顾性分析120例维吾尔族急性胰腺炎患者临床资料,分非重症急性胰腺炎和重症急性胰腺炎两组。比较两组一般资料,评估NMP联合血肌酐与住ICU、住院死亡的相关性,通过ROC曲线下面积比较急性生理学和慢性健康评分Ⅱ、中性粒细胞淋巴细胞比值、NMP联合血肌酐判断急性胰腺炎严重程度的能力。结果入院24 h内NMP、血肌酐水平重症急性胰腺炎组均高于非重症急性胰腺炎组(P<0.001);NMP联合血肌酐与住ICU、住院死亡均呈正相关(r=0.489,P<0.001;r=0.383,P<0.001);急性生理学和慢性健康评分Ⅱ与NMP联合血肌酐的ROC曲线下面积差异无统计学意义(Z=0.38,P=0.704),且均优于中性粒细胞淋巴细胞比值(Z=3.10,P=0.002;Z=2.43,P=0.016)。结论 NMP联合血肌酐可作为判断急性胰腺炎严重程度的一种简单而有效方法。
Objective To investigate the ability of neutrophil monocyte product (NMP) combined with serum creatinine to determine the severity of acute pancreatitis. Methods The clinical data of 120 Uygur patients with acute pancreatitis were retrospectively analyzed. The patients were divided into two groups: non-severe acute pancreatitis and severe acute pancreatitis. The two groups of general data were compared to evaluate the correlation between NMP combined with serum creatinine and ICU admission and hospital mortality. The acute physiology and chronic health score II, neutrophil lymphocyte ratio, NMP combined with serum creatinine The severity of inflammation. Results The levels of NMP and serum creatinine in severe acute pancreatitis group were significantly higher than those in non-severe acute pancreatitis group within 24 hours after admission (P <0.001). NMP combined with serum creatinine and ICU admission and hospitalization were positively correlated (r = 0.489, P < 0.001, r = 0.383, P <0.001). There was no significant difference in the area under the ROC curve between acute physiology and chronic health score Ⅱ and NMP combined with serum creatinine (Z = 0.38, P = 0.704) Cell lymphocyte ratio (Z = 3.10, P = 0.002; Z = 2.43, P = 0.016). Conclusion NMP combined with serum creatinine can be used as a simple and effective method to judge the severity of acute pancreatitis.