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目的 探讨近期感染与脑卒中类型的关系，近期感染在脑缺血性损伤中的作用，并对可能的机制进行探讨。方法 全面分析了１１５ 例近期无感染及３０ 例病前１ 周内有感染的脑梗死患者病因、临床及神经影像学的资料，同时检测了外周血白细胞数目、白介素－１（ＩＬ－１）、白介素－６（ＩＬ－６）、肿瘤坏死因子（ＴＮＦ）及Ｄ－二聚体含量。结果 近期有感染的脑梗死患者与近期无感染的脑梗死患者比较，入院时、入院后３ 天（ｄ）、７ ｄ 及３～４ 周神经功能缺损严重，梗死体积大，皮层梗死及心源性脑栓塞发生率高；近期有感染的脑梗死患者白细胞数，外周血ＩＬ－１、ＩＬ－６ 及Ｄ－二聚体水平明显高于无感染的脑梗死患者。结论 近期有感染的脑梗死患者脑缺血性损伤及神经功能缺损严重，心源性脑栓死及皮层梗死危险性增加，近期有感染的脑梗死患者预后不良
Objective To investigate the relationship between recent infection and stroke type, the role of recent infection in cerebral ischemic injury and to explore possible mechanisms. Methods The etiology, clinical and neuroimaging data of 115 cases of recent infection-free and 30 cases of infected patients with cerebral infarction were analyzed. The numbers of peripheral blood leukocytes, interleukin-1 (IL-1) Interleukin-6 (IL-6), tumor necrosis factor (TNF) and D-dimer levels. Results Compared with the recent non-infected patients with cerebral infarction, the patients with cerebral infarction who were infected recently had severe neurological deficits, large infarct volume, cortical infarction and cardiac output on the 3rd day (d), 7th day and 3rd to 4th week after admission The incidence of cerebral embolism is high. The number of white blood cells, the levels of IL-1, IL-6 and D-dimer in peripheral blood of patients with recent cerebral infarction are significantly higher than those of non-infected patients. Conclusion Recently, patients with cerebral infarction who have been infected with cerebral infarction have severe ischemic injury and severe neurological deficit. The risk of cardioembolic cerebral infarction and cortical infarction is increased. Recently, patients with infected cerebral infarction have a poor prognosis