本文对两种硫酸奎尼了缓释片(1号片和2号片)的制备、体外溶出和体内生物利用度进行了初步研究。1号片采用模型片的制备方法,2号片采用压制片的制备方法。两种缓释片均符合美国药典××Ⅱ版体外溶出规定,两种片剂的T_(50)分别为200min和178min。对2号片在2名受试者身上进行体内生物利用度初步测定结果表明,其吸收慢于普通片,12h以后血浓平稳。 The preparation, in vitro dissolution and in vivo bioavailability of two quinidine sulfate sustained-release tablets (tablets 1 and 2) were studied in this paper. No. 1 film using the preparation method of the tablet, No. 2 tablet using compressed tablet preparation. Both sustained-release tablets were in compliance with the United States Pharmacopoeia XX Ⅱ in vitro dissolution of the provisions of the two tablets T_ (50) were 200min and 178min. The results of in vivo bioavailability of No. 2 tablets on 2 subjects showed that the absorption was slower than that of ordinary tablets and the blood concentration was stable after 12 hours.