糖尿病肾病(DN)是糖尿病主要的慢性微血管病变,是糖尿病的主要死亡原因之一。随着糖尿病发病率的增加,DN的患病人数也在逐渐增加。对南京642例糖尿病患者肾脏病变的调查表明,DN的总发病率为47.66％,其中早期DN为34％,临床DN为13.5％。一般认为DN一旦出现临床蛋白尿(24小时尿蛋白排量>0.5 g)就变得不可逆转,肾功能将进行性下降。为了减少蛋白尿,控制病情的发展,中、西医工作者作了大量的研究和探索,现就此综述如下。 Diabetic nephropathy (DN) is a major chronic microvascular disease of diabetes and is one of the leading causes of death in diabetes. As the incidence of diabetes increases, the number of patients with DN is also gradually increasing. A survey of renal lesions in 642 diabetic patients in Nanjing showed that the overall incidence of DN was 47.66%, of which the early DN was 34% and the clinical DN was 13.5%. It is generally believed that once DN appears clinical proteinuria (> 24 g urinary protein excretion> 0.5 g) becomes irreversible, renal function will decline progressively. In order to reduce proteinuria, control the development of the disease, Chinese and Western workers made a lot of research and exploration, are summarized below.