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目的 :探讨脑卒中后继发上消化道出血 ( UDTB)的危险因素。方法 :脑卒中后 UDTB组 97例 ,单纯脑卒中组 2 574例。两组均系同期住院的脑卒中患者。对研究资料先进行单因素分析 ,然后进行多因素非条件Logistic回归模型分析。结果 :经分析筛选出意识障碍、大面积脑实质损伤、丘脑区损伤、脑干卒中、脑室出血等 5个因素为 UDTB的独立危险因素 ,而应用抑制胃酸分泌药物则是 UDTB的重要保护性因素。结论 :脑卒中后 UDTB的发生主要决定于患者意识状态和脑损伤程度及部位 ,抑制胃酸分泌类药物可有效地预防 UDTB的发生。
Objective: To explore the risk factors of secondary upper gastrointestinal bleeding (UDTB) after stroke. Methods: Ninety-seven patients in the UDTB group after stroke and 2,574 in the stroke group alone. Both groups were hospitalized stroke patients in the same period. Univariate analysis of the study data, and then multivariate non-conditional Logistic regression model analysis. Results: Five factors were identified as the independent risk factors of UDTB, such as disturbance of consciousness, large areas of parenchymal injury, damage of the thalamus, brainstem stroke and ventricular hemorrhage. UDTB was an important protective factor . Conclusion: The incidence of UDTB after stroke mainly depends on the patients' consciousness status and brain injury degree and location, and inhibition of gastric acid secretion drugs can effectively prevent the occurrence of UDTB.