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【目的】探讨清热解毒凉血方联合蒙脱石散对感染性腹泻患儿相关因子白介素8(IL-8)、白介素10(IL-10)、单核细胞核因子(NF-kB)表达的影响。【方法】随机选门诊及病房的感染性腹泻患儿162例,治疗过程中因未能坚持退出12例,最终入选150例。将150名感染性腹泻患儿按感染类型分为病毒性肠炎组和细菌性肠炎组,并随机选8名正常儿童作为正常组,观察各组治疗前相关因子的表达。并将患儿按治疗方案不同随机分为治疗Ⅰ组、治疗Ⅱ组和对照组。治疗Ⅰ组采用清热解毒凉血方灌肠;治疗Ⅱ组在治疗1组的基础上口服蒙脱石散;对照组仅口服蒙脱石散。观察治疗5d、15d前后相关因子的变化。【结果】治疗前细菌性肠炎组IL-8含量与病毒性肠炎组相比差异无统计学意义(P>0.05);细菌性肠炎组IL-10低于病毒性肠炎组(P<0.01)。治疗前治疗Ⅰ组、治疗Ⅱ组、对照组三组IL-8、IL-10、NF-kB相比差异无统计学意义(P>0.05),治疗5d、15d后各自与治疗前相比均明显降低(P<0.01);治疗Ⅱ组优于治疗Ⅰ组及对照组(P<0.05)。【结论】IL-10可作为鉴别细菌性或病毒性肠炎的辅助诊断方法;清热解毒凉血方联合蒙脱石散能明显降低感染性腹泻患儿相关因子的表达,促进患儿早日康复。
【Objective】 To investigate the effect of Qingre Jiedu Shexue Recipe combined with montmorillonite powder on the expression of interleukin 8 (IL-8), interleukin 10 (IL-10) and monocyte nuclear factor (NF-kB) in children with infectious diarrhea . 【Methods】 A total of 162 children with infectious diarrhea were selected randomly from the outpatient department and ward. During the treatment, 12 patients were excluded and 150 were finally selected. According to the type of infection, 150 children with infectious diarrhea were divided into viral enteritis group and bacterial enteritis group. Eight normal children were randomly selected as the normal group. The expression of related factors in each group before treatment was observed. Children were randomly divided into treatment group Ⅰ treatment group Ⅱ, treatment group Ⅱ and control group. Treatment Ⅰ group with Qingrejiedu cooling blood enema; treatment group Ⅱ in the treatment group 1 oral montmorillonite powder; the control group only oral montmorillonite powder. The changes of related factors before and after 5 days and 15 days of treatment were observed. 【Results】 There was no significant difference in the content of IL-8 between the group of bacterial enteritis and the group of viral enteritis before treatment (P> 0.05). The level of IL-10 in the group of bacterial enteritis was lower than that of the group of viral enteritis (P <0.01). There were no significant differences in the levels of IL-8, IL-10 and NF-kB between groupⅠ, groupⅡ and groupⅢ before treatment (P> 0.05), after treatment for5d and15d (P <0.01). The treatment group Ⅱ was better than the treatment group Ⅰ and the control group (P <0.05). 【Conclusion】 IL-10 can be used as an auxiliary diagnostic method to distinguish bacterial or viral enteritis. Detoxifying and detoxifying cool blood combined with montmorillonite powder can significantly reduce the expression of related factors in children with infectious diarrhea and promote the early recovery of children.