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目的探讨n-3脂肪酸的膳食摄入量与结直肠癌发生风险的关系。方法计算机检索PubMed、EMBASE、CNKI数据库和Cochrane图书馆已发表的相关研究文献。由2名评价者独立筛选文章、提取数据及评价纳入研究的质量,采用STATA11.0软件完成Meta分析。结果最终共纳入7项病例对照研究和4项前瞻性队列研究,共253 479名研究对象。n-3脂肪酸膳食摄入最高量部分的人群相比摄入最低量部分的人群发生结直肠癌的风险是0.88(95%CI:0.68~1.13;P=0.316,4分类,6项研究)和1.03(95%CI:0.92~1.16;P=0.606,5分类,5项研究)。结论 n-3脂肪酸的摄入量与结直肠癌的发生没有显著相关性,膳食摄入n-3脂肪酸与结直肠癌的发生风险之间的关系尚需进一步研究证实。
Objective To investigate the relationship between the dietary intake of n-3 fatty acids and the risk of colorectal cancer. Methods The computer-aided search of PubMed, EMBASE, CNKI database and the published research literature of Cochrane Library. Two reviewers independently screened articles, extracted data and evaluated the quality of the included studies. Meta-analysis was performed using STATA11.0 software. Results A total of 7 case-control studies and 4 prospective cohort studies were enrolled in a total of 253 479 subjects. The risk of developing colorectal cancer was 0.88 (95% CI: 0.68 to 1.13; P = 0.316, 4 categories, 6 studies) for those with the highest intake of n-3 fatty acids compared to the lowest intake 1.03 (95% CI: 0.92-1.16; P = 0.606, 5 categories, 5 studies). Conclusion There is no significant correlation between n-3 fatty acid intake and the incidence of colorectal cancer. The relationship between n-3 fatty acid intake and the risk of colorectal cancer remains to be confirmed.