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对 32例丙型病毒性肝炎患者随机配对分为干扰素治疗组 ( 16例 ,治疗组 )和常规护肝降酶治疗组 ( 16例 ,对照组 )进行疗效对比观察 ,疗程结束后 ,两组 AL T应答差异无显著性 ( P>0 .0 5) ,抗 HCV和 HCV- RNA阴转率治疗组分别为 7/ 14、8/ 12 ,对照组分别为 1/ 14和 0 / 11,差异有显著性 ( P<0 .0 5)。治疗组在治疗中和结束后发生 2例急性肝坏死 ,1例急性左心衰竭等严重并发症。对干扰素治疗丙型肝炎的监测方法 ,疗效评价及副作用提出讨论
32 patients with viral hepatitis C were randomly assigned to interferon treatment group (16 patients) and conventional hepatoprotease treatment group (16 patients, control group) to compare the efficacy of treatment, after the end of the treatment, two groups There was no significant difference in the ALT response (P> 0.05), anti-HCV and HCV-RNA negative conversion rate of treatment group were 7 / 14,8 / 12, the control group were 1/14 and 0/11, respectively There was significant (P <0.05). In the treatment group, two cases of acute hepatic necrosis and one case of acute left heart failure occurred during and after treatment. The method of interferon treatment of hepatitis C, efficacy evaluation and side effects are discussed