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目的观察大剂量甲基强的松龙治疗百草枯的疗效。方法将29例百草枯中毒患者随机分为两组,对照组12例应用常规治疗加地塞米松,治疗组17例在常规治疗基础上加大剂量甲基强的松龙应用。结果在研究两组病死率期间,两组基本状况相似,对照组的肝功能损害、肾功能损害、中毒性心肌炎和低氧血症的发生率分别为25.0%、58.3%、50.0%和75.0%;而治疗组分别为35.3%、52.9%、47.1%和41.2%,两组间无统计学差异。而对照组的住院时间(11.75±6.04)短于治疗组(21.64±7.83),P<0.05。对照组病死率(75.0%,9/12)高于治疗组(29.4%,5/17),P<0.05。结论与地塞米松相比较,大剂量甲强龙治疗百草枯中毒,能够延长患者的住院时间,降低病死率。
Objective To observe the effect of high dose methylprednisolone on paraquat. Methods Twenty-nine patients with paraquat poisoning were randomly divided into two groups. In the control group, 12 cases were treated with conventional therapy plus dexamethasone. The treatment group was given 17 cases of methylprednisolone on the basis of routine treatment. Results During the study of the two groups, the basic conditions were similar between the two groups. The incidence of liver dysfunction, renal dysfunction, toxic myocarditis and hypoxemia were 25.0%, 58.3%, 50.0% and 75.0% respectively in the control group, ; While the treatment group were 35.3%, 52.9%, 47.1% and 41.2% respectively, with no significant difference between the two groups. The length of stay in the control group (11.75 ± 6.04) was shorter than that in the treatment group (21.64 ± 7.83), P <0.05. The mortality of the control group (75.0%, 9/12) was higher than that of the treatment group (29.4%, 5/17), P <0.05. Conclusion Compared with dexamethasone, high-dose methylprednisolone treatment of paraquat poisoning can prolong the hospital stay and reduce the mortality.