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目的:讨胃肿瘤患者凝血与纤溶系统功能指标的变化,以及了解胃肿瘤患者凝血与纤溶系统功能改变的意义。方法:用SYSMEXCA-7000全自动血凝分析仪分别测定62例胃肿瘤患者、42例胃间质瘤患者、50例胃平滑肌瘤患者以及46例健康体检者的凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)含量及D-二聚体(D-dimer)水平。结果:肿瘤患者的PT、TT、APTT、FIB与胃间质瘤患者、胃平滑肌瘤患者以及健康体检者相比均显著降低,差异有统计学意义(P<0.05),且D-dimer显著升高,差异有统计学意义;胃间质瘤患者的PT、TT、APTT、FIB与健康体检者相比均降低,差异有统计学意义(P<0.05),且D-dimer升高,差异有统计学意义。结论:肿瘤患者与胃间质瘤患者常伴随高凝与纤溶亢进状态,监测患者体内PT、TT、APTT、FIB及D-dimer变化可有效预防血栓性疾病或出血性疾病的发生具有重要意义以及为临床治疗提供依据。
Objective: To discuss the changes of coagulation and fibrinolytic system functional indexes in patients with gastric cancer, and to understand the function of coagulation and fibrinolysis system in patients with gastric cancer. Methods: The prothrombin time (PT), serum creatinine (PT) in 62 patients with gastric cancer, 42 patients with gastric stromal tumor, 50 patients with gastric leiomyoma and 46 healthy individuals were measured by SYSMEXCA-7000 automatic hemagglutination analyzer. Thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB) content and D-dimer level. Results: PT, TT, APTT and FIB in tumor patients were significantly lower than those in patients with gastric stromal tumors, gastric smooth muscle tumors and healthy subjects (P <0.05), and D-dimer was significant (P <0.05), and the D-dimer increased, the difference was statistically significant; PT, TT, APTT, FIB in patients with gastric stromal tumors were significantly lower than those in healthy subjects There is statistical significance. Conclusion: Patients with tumors and patients with gastric stromal tumors often hypercoagulable and hyperfibrinolytic state monitoring of patients with PT, TT, APTT, FIB and D-dimer changes can effectively prevent the occurrence of thrombotic disease or hemorrhagic disease is of great significance As well as provide the basis for clinical treatment.