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近年研究表明骨髓间充质干细胞(MSCs)移植能使局部心肌病变(如心肌梗死所致心力衰竭)的心功能恢复[13]。本研究采用阿霉素建立心肌病的动物模型,MSCs不经体外诱导直接移植到此模型的心室肌内,观察MSCs移植对弥漫性心肌病变的心功能的影响,为MSCs的临床应用提供实验依据。1.材料
In recent years, studies have shown that bone marrow mesenchymal stem cells (MSCs) transplantation can restore cardiac function of local myocardial lesions (such as heart failure caused by myocardial infarction) [13]. In this study, doxorubicin was used to establish animal models of cardiomyopathy. MSCs were transplanted directly into the ventricular myocardium without inducing in vitro. The effects of MSCs transplantation on the cardiac function of diffuse cardiomyopathy were observed to provide experimental evidence for the clinical application of MSCs . Material