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目的观察甲羟孕酮联合去氧孕烯炔雌醇片对围绝经期功血症状的临床疗效。方法选取本院2015年1月~2016年1月期间收治的108例围绝经期功能失调引起的不规则出血患者,依据治疗药物不同分为观察组(甲羟孕酮联合去氧孕烯炔雌醇片)和对照组(去氧孕烯炔雌醇片),每组各54人。连续用药90天,对比分析两组患者血清性激素水平、疗效变化、复发率及不良反应发生率。结果经过90天的跟踪治疗,两组患者在围绝经期止血时间均显著短于治疗前;与对照组相比,观察组患者治疗前后血清激素水平均显著降低(P<0.05),对照组治疗效果不显著;与对照组相比,观察组患者的复发率和治愈率均显著提高(P<0.05)。结论采用甲羟孕酮联合去氧孕烯炔雌醇片和单纯去氧孕烯炔雌醇片治疗,对围绝经期功能失调性子宫出血均有良好效果,与单纯去氧孕烯炔雌醇治疗相比,联合甲羟孕酮可以有效降低围绝经期功血复发率和提升患者满意度,改善机体血液中激素水平,使用甲羟孕酮联合去氧孕烯炔雌醇片治疗围绝经期功血方法值得参考。
Objective To observe the clinical effects of medroxyprogesterone combined with ethinyl ethinyl estradiol on perimenopausal dysfunctional uterine bleeding. Methods A total of 108 patients with irregular bleeding caused by peri-menopausal dysfunction who were treated in our hospital from January 2015 to January 2016 were selected and divided into observation group (Medroxyprogesterone combined with norgestrel Alcohol tablets) and control group (desogestrel ethinyl estradiol tablets), each of 54 people. Continuous medication for 90 days, comparative analysis of two groups of patients with serum sex hormone levels, efficacy changes, recurrence rates and adverse reactions. Results After 90 days of follow-up treatment, the bleeding time of both groups was significantly shorter than that before treatment in the perimenopausal period. Compared with the control group, the levels of serum hormone in the observation group decreased significantly (P <0.05) The effect was not significant. Compared with the control group, the recurrence rate and cure rate in observation group were significantly increased (P <0.05). CONCLUSION: Medroxyprogesterone combined with norgestrel and ethinyl estradiol alone have good effect on dysfunctional uterine bleeding during peri-menopausal period, Medroxyprogesterone acetate combined with medroxyprogesterone acetate can effectively reduce the recurrence rate of perioperative menstrual blood and improve patient satisfaction, improve the body’s blood hormone levels, the use of medroxyprogesterone combined with norgestrel ethinyl estradiol tablets in the treatment of menopause Worthy of blood method is worth considering.