作者在成功的研制出一种非丁香酚类牙周塞治剂一Ｓｎｅ一ｐａｃｋ（Ｓｐ）的基础上，进行了细胞及组织毒性研究，并与Ｃｏｅ一ｐａｋ（Ｃｐ）、氧化锌丁香酚牙周塞治剂（Ｃｅ）做比较。结果表明：三种牙周塞治剂均无明显细胞毒性。Ｓｐ引起结缔组织产生６０％的中度反应、４０％的轻度反应。Ｃｐ的重、中、轻度友应分别为４６．１％、３３．５％和１５．４％；Ｃｅ分别为５３．４％、３３．３％和１３．３％。提示：ｓｐ的结缔组织毒性明显小于Ｃｐ和Ｃｅ。 On the basis of a Sne-pack (Sp), a non-eugenol periodontal remedy successfully developed, the study of cell and tissue toxicity was carried out and compared with Coe-Pak (Cp), zinc oxide eugenol periodontal treatment (Ce) for comparison. The results show that: three kinds of periodontal agents have no obvious cytotoxicity. Sp causes connective tissue to produce a moderate response of 60% and a mild response of 40%. The heavy, moderate and mild friends of Cp should be 46.1%, 33.5% and 15.4% respectively, and Ce should be 53.4%, 33.3% and 13.3% respectively. Tip: sp connective tissue toxicity was significantly less than Cp and Ce.