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【目的】了解新生儿脐炎病原菌分布及耐药性,为合理选用抗菌药物提供依据。【方法】150例新生儿脐炎患儿作脐炎分泌物及血液病原菌分离和药敏实验,并对药敏结果进行分析。【结果】150例脐炎患者脐分泌物培养共分离出病原菌136株,主要为金黄色葡萄球菌(n=40)、表皮葡萄球菌(n=20)、大肠埃希氏菌(n=18)、阴沟肠杆菌(n=11)、肺炎克类雷伯菌(n=10)。革兰阴性杆菌对亚胺培南、美洛培南、头孢吡肟、哌拉西林/他唑巴坦、阿米卡星等敏感率较高,革兰阳性球菌对万古霉素、替考拉宁、呋西地酸、呋喃妥因、奎宁始霉素-达福普汀等敏感率较高。【结论】及时总结分析新生儿脐炎病原菌分布及耐药性,对于控制耐药菌株传播具有十分重要意义。
【Objective】 To understand the distribution and drug resistance of neonatal omphalitis in order to provide a basis for rational use of antimicrobial agents. 【Methods】 150 cases of neonatal omphalitis in children with omphalitis secretion and blood pathogens isolation and drug susceptibility tests, and drug susceptibility results were analyzed. 【Results】 136 strains of pathogens were isolated from 150 cases of omphalitis. The main pathogens were Staphylococcus aureus (n = 40), Staphylococcus epidermidis (n = 20) and Escherichia coli (n = 18) , Enterobacter cloacae (n = 11), Klebsiella pneumoniae (n = 10). Gram-negative bacilli for imipenem, meropenem, cefepime, piperacillin / tazobactam, amikacin and other high sensitivity, gram-positive cocci of vancomycin, Ning, Fu Xidi acid, nitrofurantoin, Quinidine Daptomycin - dalfopristin and other high sensitivity. 【Conclusion】 It is of great importance to control the distribution of drug-resistant strains in time to analyze the distribution and drug resistance of neonatal omphalitis.