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目的探讨危险信号分子热高迁移率族蛋白HMGB1和热休克蛋白HSP70在子痫前期(preeclampsia,PE)胎盘组织中的表达。方法采用免疫组织化学方法检测59例重度PE、22例正常晚孕胎盘中HMGB1和HSP70的表达。结果与正常妊娠晚期对照组相比,重度子痫前期胎盘中HMGB1表达显著的上升(P<0.05);HMGB1在早发型子痫前期胎盘的表达比晚发型PE胎盘显著的上升(P<0.05);与重度PE合并FGR组相比,重度PE无FGR组胎盘中HMGB1表达也显著的上升(P<0.05),但与正常妊娠晚期对照组相比差异无统计学意义(P>0.05)。HSP70在重度子痫前期胎盘的表达比在正常足月胎盘增加,但差异无统计学意义(P>0.05);HSP70在早期子痫前期胎盘的表达比晚发型PE胎盘减少,但差异无统计学意义(P>0.05);与重度PE无FGR组相比,重度PE合并FGR组胎盘中HSP70表达增加,但差异无统计学意义(P>0.05)。结论滋养细胞HMGB1高表达可能是早发型重度子痫前期发病的原因之一,危险信号分子有可能成为治疗PE的一个重要靶点。
Objective To investigate the expression of heat shock protein HMGB1 and heat shock protein HSP70 in placenta of preeclampsia (PE). Methods Immunohistochemistry was used to detect the expression of HMGB1 and HSP70 in 59 cases of severe PE and 22 cases of normal pregnancy. Results Compared with the normal control group, HMGB1 expression in severe preeclampsia was significantly increased (P <0.05). The expression of HMGB1 in preeclampsia placenta was significantly higher than that in late onset PE placenta (P <0.05) Compared with FGR group, the expression of HMGB1 in severe PE without FGR group was significantly increased (P <0.05), but there was no significant difference compared with normal pregnancy group (P> 0.05). The expression of HSP70 in severe preeclampsia placenta increased more than that in normal term placenta, but the difference was not statistically significant (P> 0.05). HSP70 expression in early preeclampsia placenta was lower than that in late onset PE placenta, but the difference was not statistically significant (P> 0.05). Compared with severe PE without FGR group, the expression of HSP70 increased in placenta of severe PE with FGR group, but the difference was not statistically significant (P> 0.05). Conclusion High expression of HMGB1 in trophoblast cells may be one of the causes of early onset severe preeclampsia. Hazard signaling molecules may become an important target for the treatment of PE.