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采用热熔分散法制备不同处方的普鲁托品固体脂质纳米粒用于透皮给药。结果以三硬脂酸甘油酯为脂质材料、大豆磷脂为乳化剂的制品粒径最小[(126.2±1.7)nm]、包封率最高(92.7%)。体外透皮试验表明,该制品12 h累积渗透率为78.5%,明显高于溶液组(32.4%)。并且,该制品对Freund’s完全佐剂所致的佐剂性关节炎大鼠有较强的疗效,抗炎活性与扶他林组相当。
Plutonium solid lipid nanoparticles with different prescriptions were prepared by hot melt dispersion method for transdermal administration. Results The particle size of the product with glycerol tristearate as the lipid material and soybean lecithin as the emulsifier was the smallest [(126.2 ± 1.7) nm], the highest encapsulation efficiency was 92.7%. In vitro transdermal test showed that the cumulative permeation rate of the product in 12 h was 78.5%, which was significantly higher than that of the solution group (32.4%). And, the product has a strong curative effect on Freund’s complete adjuvant-induced adjuvant arthritis rats, and the anti-inflammatory activity is comparable to that of the fondaparinux group.