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应用肿瘤相关糖蛋白７２抗原（ＴＡＧ－７２）的单抗７２－４５及两种凝集素ＰＮＡ和ＤＢＡ对不同组织分型的大肠癌及癌旁组织进行了研究。结果表明：大肠癌中ＴＡＧ－７２抗原及ＰＮＡ受体的表达阳性率分别为８５．３％和８９．３％，ＤＢＡ受体呈阴性；在癌旁组织中三者的表达阳性率分别为５０％、５３．３％和６３．３％；在正常大肠粘膜中ＴＡＧ－７２抗原及ＰＮＡ受体均呈阴性，而ＤＢＡ受体全部呈阳性。由此认为７２－４５单抗和ＰＮＡ可做为大肠癌的有效标记物，有助于大肠癌的诊断和预后。
Using monoclonal antibody 72-45 with tumor-associated glycoprotein 72 antigen (TAG-72) and two lectins PNA and DBA, different types of colorectal cancer and adjacent tissues were studied. The results showed that the positive rates of TAG-72 antigen and PNA receptor in colorectal cancer were 85.3% and 89.3%, respectively, and the DBA receptor was negative; the positive rate of the expression in the paraneoplastic tissue was 50. %, 53.3%, and 63.3%; TAG-72 antigen and PNA receptor were negative in normal colorectal mucosa, and all DBA receptors were positive. This suggests that 72-45 mAb and PNA can serve as effective markers for colorectal cancer, which contributes to the diagnosis and prognosis of colorectal cancer.