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临床实践已证实乙胺碘呋酮是一种疗效高,疗效长,毒性低的较理想较安全的广谱抗心律失常药。随着临床的广泛应用,特别是与洋地黄合用于治疗心衰合并心律失常时,副作用明显而严重。现将我院二例报告如下: 例一 夏××,男性,56岁。因冠心病,心房颤动2——3年入院治疗。首先给予乙胺碘呋酮片0.1,每天3次,连用7天(总量约2.1g),疗效欠佳,而加用地戈辛0.25mg,每天1次口服,在用地戈辛后第3天(总量约0.75mg),患者心率由90次/分下降至45～55次/分。即停用地戈辛与乙胺碘呋酮。给予一般处理,患者心率维持在50次/分左右将近1个月始恢复到心率70次/分。
Clinical practice has confirmed that amiodarone is a more effective, long-acting, low toxicity, the more ideal and safer broad-spectrum antiarrhythmic drugs. With the wide range of clinical applications, especially with digitalis combined for the treatment of heart failure with arrhythmia, the obvious and serious side effects. Now report two cases in our hospital are as follows: A summer × ×, male, 56 years old. Due to coronary heart disease, atrial fibrillation 2 - 3 years admitted to hospital. First give amiodarone tablets 0.1, 3 times daily for 7 days (total about 2.1g), poor efficacy, and add Digoxin 0.25mg, 1 day orally, in the third days after the geoxie (Total about 0.75mg), the patient’s heart rate decreased from 90 beats / min to 45 ~ 55 beats / min. That is to stop geoxin and amiodarone. Give the general treatment, the patient’s heart rate remained at about 50 beats / min almost 1 month to return to heart rate 70 beats / min.