肾脏是主要排泄器官,很多药物均由肾脏排除,另一些药物部分由肾脏排除。肾衰时,主要经肾排除的药物排除明显减慢,半衰期明显延长。如卡那霉素,肾功正常时半衰期仅为24小时,而肾衰时可超过70小时。这种情况下,如果按常规投给肾功正常病人同样剂量的药物,必将引起药物蓄积和中毒。因此,在临床治疗中,当采用主要经肾排除的药物对伴有肾功 The kidneys are the main excretory organs, many are eliminated by the kidneys, and some are excluded by the kidneys. Renal failure, the main elimination of the drug by the kidneys significantly slowed down, significantly extended half-life. Such as kanamycin, normal renal function half-life of only 24 hours, and renal failure can be more than 70 hours. In this case, if according to the conventional cast the same dose of normal renal patients with drugs, will inevitably lead to drug accumulation and poisoning. Therefore, in clinical treatment, when using the main drugs excluded by the kidney associated with renal function